Butyrate Interruption, Kind of

My husband always passes along mainstream news clips on health that he sees relating to my studies.  I think he is super happy that we found this new way of eating and thinking, despite our doc-in-a-box trained brains.  (It has a made a huge difference in the health of every single family member.)

Anyhow here is today’s tidbit passed on to me by husband who noticed the word BUTYRATE.  The article relates to “potential new ways to prevent colon cancer” and discusses how there is growing evidence for a link between bacteria and colon cancer:

“Ahn and her colleagues also noticed lower levels of Clostridia – “good” bacteria – in the gut of cancer patients.  Clostridia – of which there are several forms – is important in the fermentation and digestion of fiber and carbohydrates.  Clostridia also creates a chemical butyrate, which is believed to moderate inflammation and cancerous mutations in the colon.”  (Emphasis mine)

So I continue to encourage you to eat for your bacteria!  Whole foods!  And I hope with the butyrate series that’s running, that you can say when you stumble across these news clips telling you it comes down to bacteria and the products they help make, “Yeah.  I knew that.  That’s old news.”

What you eat matters, from colon cancer to headaches to runny noses!  Don’t eat processed foods!  Here is the link to the article above:

Research points to potential new ways to prevent colon cancer


30 thoughts on “Butyrate Interruption, Kind of

    1. thehomeschoolingdoctor Post author

      Mmmmmm. NONE. To make sure I was being fair, I asked my husband also. He remembered none. We did learn about it way back in organic chemistry in undergraduate school, but only as it related to structure. I think the medical doctors who may know something about butyrate as a supplement would maybe be gastroenterologists (for use in unresponsive inflammatory bowel disease patients) and hematologists/oncologists (it is being used in several trials now for cancers and blood disorders). They probably would have learned from residency rather than med school.

      1. All Seasons Cyclist

        I live in the Chicago area and we have had a lot of young friends who were med students (yes, we have a lot of gang violence, but we also have great med schools). Anyway, I always ask them how much time they spent studying nutrition — that usual answer is, “One lecture, and that was mainly on malnutrition.”

      2. thehomeschoolingdoctor Post author

        I know! Do you know how you feel when you see an injustice? And you just want to change it? You can’t stand by and do nothing? This is the only something I have to give right now. That and getting my close med-school friends on board and sharing with good friends who are interested. Sending them links and research articles. I’m very angry yet the only way to effect change is to be a little stream and keep running over the rock; if you come on too hard, you’re labeled and not listened to. Our required continuing medical education is horrible. Just horrible. And expensive. Sorry for the rant. Keep warm in Chicago and stay out of harms way. 🙂

  1. andthreetogo

    This all is so interesting to me! I love to be able to eat whole foods and did well with that when back in California. It is a little difficult to do while on the road for so long. But I try where I can 🙂

      1. andthreetogo

        That is very true. The amount of dairy and wheat is fairly low 🙂 the hardest part of eating well on the road is trying not to eat home-y comfort foods. The other countries were much easier to fall into that trap, Thai food is my favorite though, so I rarely feel the need to have anything else.

  2. illys2013

    I just want to say thanks for your posts. Really, a big thanks. I’m adding a good bit of what I learn into my notes on type 1 diabetes and insomnia. Have you seen any info or have any thoughts on butyrate helping to differentiate islet beta cells and glycogen -producing cells in the pancreas during the maturation of pancreatic stem cells? I’ve pegged down one study so far from 1988, but that’s still hardly near conclusive.
    Cheers and all. 🙂

      1. illys2013

        Thanks! 😉
        Here’s the one indicating a possible butyrate pancreatic role with islet cells: http://www.ncbi.nlm.nih.gov/m/pubmed/2843409/
        I’ll look at the thyroid link now.
        The idea of Butyrate activating insulin-pancreatic cells is.. Making sense. Only a fraction of type 1 diabetics test positive for beta cell antibodies and as missing fasting C- peptide completely. Type 1a and type 1b. A drop in an ingredient in mRNA expression would really push the beta cells dormant.
        D3 activity is another item in relation to neutral health and beta cell activity. Canadian research in the past decade pointed out many D3 receptors on beta cell walls, and one of its roles is correct expression of genes.
        Another pro-gut diversity argument is segmented filamentous bacteria (http://www.ncbi.nlm.nih.gov/m/pubmed/21709219/)
        Bless and cheers again. ☺

      2. thehomeschoolingdoctor Post author

        Loosely related, as I was reading the other day on brewer’s yeast, someone mentioned how Type ones had antibodies to glutamic acid. Just throwing it out there. 🙂 Like you need more!

        Thanks for sharing! Butyrate and eating to support that production is just really important, I’m continuing to gather!

      3. illys2013

        Sounds interesting, think maybe you could post me some source material? It takes some real sorting to comb through all the data. 😉

      4. thehomeschoolingdoctor Post author

        I remembered wrong. It was antibodies to glutamic acid decarboxylase, not glutamic acid. But I read very briefly about it because of your comments, and it was pretty cool. Thanks. Here is an article. If it interests you and you want to follow it, there were quite a few more. I just Googled–incorrectly–antibodies to glutamic acid in diabetes, and many articles of primary research and review came up. I didn’t know that we could test for this and it has implications.


      5. illys2013

        No kidding on the implications! Plus the extra links to gut disbiosis. In NOD mice (types that develop type 1 D), the levels of segmented filamentous bacteria in the ileum of the small intestine was directly proportional to how fast the mice went from diagnosis to full insulin dependency. The SFB have a function of training Th17 immune cells, and the mice which lost beta cell function fastest were deficient in that particular strain of gut flora. It exists in humans too, though in a very small percentage of the population studied.

        It’s enough to look at the people who are needing FMT transplants in the states and learning what sort of challenges, side effects, successes and failures they experience. There are many variables to the business of gut biota, far beyond just changing out the colonies! Especially in an autoimmune disorder where candidiasis has had a good chance to get settled.
        However, the findings are enough to give me a little reason to raise my brow at the two cases of reversed type 1 D that I have heard of.
        Personally better digestion, energy and sleep is reason enough for Butyrate and some sauerkraut and kombucha. 😉

      6. thehomeschoolingdoctor Post author

        It all blows my mind. And the idea that we are simply vectors just trying to feel good on the backs of something we don’t understand.

        If you go the supplement butyrate route, I’d love to hear results. If you go the food butyrate production route, I’d love to hear too! And maybe other readers of comments would too.

        Have a good weekend.


      7. illys2013

        Thank you, and likewise!
        I’m just using the sodium Butyrate (with potassium in the capsule) at the moment.
        Real results take 3, 6, 9 months or more… And I started just two days ago.

        I want to go the food route, supplements are drops in the bucket, like I said, considering how much more nutrients you get from a good gut microbiome.
        Cheers and bless to you and yours~

      8. illys2013

        No source other than my own thoughts in this case, since it takes time to make correlations between Butyrate supplementation and insulin usage, digestive health and mental clarity!
        I’ve been using it about seven days now, and I can report I’ve been able to weather what is usually an awful session of insomnia with a lot more calm and clarity of thought. And I’ve been able to sleep at least 3-6 hours per night. I’m dealing with an infected root canal right now though, and it’s interfering with a lot of things >.< Dental appointment in two days!

        The anti-inflammatory properties have been a big benefit (I tried a colonic treatment of Butyrate), I slept quite well that night and had a very healthy BM in the morning. Normally an insomnia period completely shuts down my digestive tract. Right after the colonic, I felt sleepy and warm and cheerful, and the feeling of.. Hrmmh.. It's like I could feel my gut relaxing, similar to the feeling before bloating sets in, but instead of the hollow ugh feeling of gas being formed, it felt… Healthy? Calm. I guess it was a feeling of less stress than the issues of a normally problematic digestion process.

        That's what I can report right now. 🙂 I've read one forum thread on curezone of a person using Butyrate and borate to conquer his candidiasis. That was interesting. Thrush and digestive issues are rather multifaceted though, especially for discussing in a blog comment thread. 😉

      9. thehomeschoolingdoctor Post author

        Multi-faceted to say the least! That would be great if the butyrate kept helping! Would love to hear an update later on the blood sugars! Butyrate and borate. More reading here… 🙂

      10. illys2013

        Further and further down the rabbit hole we go! There’s lots of sites about using borax as a very dilute drinking water addative, about it being targeted as part of a conspiracy, of this and that and the other thing. Basically it’s a good antifungal. Sprinkling it at the base of an Apple tree eradicates root in the trunk. It’s a mineral that anaerobic soil bacteria have trouble neutralizing, but which contributes strongly to the healthy cell walls of crops. I’d start reading from that angle! Gardening is great. 🙂
        Boron is used interchangeably with magnesium in the body, and promotes estrogen levels. It helps the body retain magnesium, and displaces fluoride in many types of soft tissues.

  3. illys2013

    Heeh! I’ve already plumbed a good amount of them, about two years ago. 😉
    The effects of supplemental boron are subtle but good. If you’re eating plenty of Apple’s, pears, etc, supplemental shouldn’t be necessary.


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